日 時：2019年11月27日（水） 12:00-13:00
場 所：筑波大学 医学エリア 睡眠医科学研究棟 1F 講堂 
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利用停留所（関東鉄道バス）：筑波大学中央行き又は筑波大学循環バス「追越学生宿舎前」
演者：Dr. Henrik Bringmann
Full Professor of Animal Physiology/ Neurophysiology (W3), University of Marburg, Germany
演題:“ Sleep: A worm’s eye view”
要旨: Sleep is conserved from jellyfish to humans and can thus be studied in simple model systems. Perhaps the simplest yet molecularly accessible model system that sleeps is C. elegans. How and why does a simple animal such as “the worm” sleep? The answers to this question can shed light on the fundamental reasons for how and why we sleep. We are applying a combination of genetics, functional imaging, optogenetics, and physiological analysis to find out how and why C. elegans sleeps. We showed that C. elegans requires a single sleep-active neuron called RIS to induce sleep. RIS is controlled by upstream circuits that measure and translate wakefulness into sleep. Cellular stress activates RIS through EGFR signaling and through the stress-sensing ALA neuron, thus increasing sleep. Without sleep, larvae show an increased progression of aging phenotypes, that decreases the rate of survival. Thus, sleep in C. elegans is ultimately simplified: It requires a single sleep-active neuron that is controlled by upstream circuits and responds to sleep need. Sleep appears to serve basic functions that include counteracting the progression of aging phenotypes.
詳細はこちらからもご覧になれます：http://wpi-iiis.tsukuba.ac.jp/japanese/seminar
問い合わせ：国際統合睡眠医科学研究機構 029-853-5857（内線5857）