セミナーは英語で行われます。
This seminar will be held in English.
生命システム医学専攻および疾患制御医学専攻の科目「医学セミナー」の対象です。
This seminar is one of the seminars for the subject “Seminar in Medical Sciences” in Doctoral Programs in Biomedical Sciences and Clinical Sciences.
【演題】
Targeting Innate Immunity in Treating Autoimmune and Inflammatory Diseases
【講師】
Dr. Lih Ling-Lin
【所属】
Senior Director
Head of Innate Immunity of Inflammation and Immunology Research Unit in Pfizer
【日時】
平成29年10月12日（木）15：00-17：00
【場所】
医学学群棟4A411
【Abstract】
Innate immune system detects danger signals derived from microbial products and endogenous ligands. These danger signals can initiate and perpetuate inflammation and autoimmunity via recognition of pattern recognition receptors such as Toll like receptor (TLR). We aim to develop transformative therapies in treating patients with autoimmune and inflammatory diseases by targeting danger signal pathways contributing to key disease mechanisms. IRAK4 is an essential kinase that mediates TLR and IL-1R signaling. We have developed a potent and selective IRAK4 inhibitor with a potential to become a novel and transformative therapy in treating autoimmune diseases such as Rheumatoid Arthritis and Lupus.